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Given that various chemical substances have been identified as neurotransmitters/neuromodulators in mammals, eliciting long-distance ionic responses that effectively mediate neurotransmission, identification of more systematic signaling molecules in the future would offer new insights into the complex systemic defense signaling in plants

The role of mGlu receptor signalling in pain modulation was recently reviewed in detail [36]

[] Additionally, SCFAs inhibit neuroinflammation via the vagus nerve and the hypothalamicpituitaryadrenal axis, ameliorating leptin and insulin resistance

doi: 10.1210/en.2015-1546

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