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Description

10.1007/s00210-024-03485-x 48 WellmanA

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Hepatology 58 , 13151325 (2013)

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The entry of -KG into the TCA cycle is highly regulated: Pyruvate Dehydrogenase Complex (PDC): The conversion of pyruvate to acetyl-CoA is tightly regulated by the PDC complex, which can be inhibited by acetyl-CoA (feedback inhibition) and activated by ADP

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The molecule loses biological activity through hydrolysis, oxidation, or aggregation while the solution still looks clear

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regulatory status may change, and readers should check current MHRA and ClinicalTrials.gov listings for the latest information

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