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These effects may lead to temporary or permanent infertility, impaired spermatogenesis or oogenesis, and increased risk of congenital anomalies in the event of conception during treatment
This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
The high-risk discovery phase was underwritten by taxpayers, and the product development phase by private firms
5 Characterization of Lysine 48 mutants of GPX4 in cells and in vitro
Beta diversity Beta diversity was determined using the unweighted UniFrac, weighted UniFrac, and BrayCurtis dissimilarity measures
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