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While human evidence is still limited, the warning remains due to: persistent concern about thyroid proliferation lack of long-term human safety data increased calcitonin levels in some patients Related: Black Box Warnings Potential Long-Term Neurological Effects Because GLP-1 receptors exist in the brain, long-term use may influence: mood regulation cognition reward systems appetite pathways Emerging reports suggest possible risks: depression anxiety emotional blunting reduced hunger signaling long-term Research is ongoing
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What makes it biochemically unique: it can only be synthesized by certain fungi and bacteria
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Shetty A, Kantarjian HM, Champlin RE, Borthakur G, Badar T, Garcia-Manero G, Andersson BS, Oran B, Ciurea SO, Konopleva M, Andreeff, M, Kornblau SM, Wierda WG, Pierce S, Ravandi F, Cortes JE
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