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When both systems are involved, the clinical picture becomes more nuanced
One reason high-quality carbs make such a difference is that they contain fermentable fibers that feed beneficial gut microbes
doi: 10.1016/j.cels.2016.08.011 201 SteinerDJKimAMillerKHaraM
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Mechanistic insights from the REMODEL trial further support its role, identifying improvements in renal microvascular function through reduction of kidney fat, improved glomerular hemodynamics, attenuation of endothelial injury via metabolic reprogramming, and decreased inflammation and fibrosis
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