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In such cases, the focus should shift to investigating potential underlying causessuch as myeloproliferative disorders, liver disease, or renal dysfunctionrather than attributing symptoms to the elevated B12 itself

So far, the Negro has been absorbing and handling all this waste, but for how long? In March, the UEA research team presented the results of their Negro River study

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

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When levels drop, the effects can be wide-ranging and often mistaken for everyday stress or ageing