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This stepwise dosing approach was designed to minimize gastrointestinal symptoms (nausea, vomiting, and diarrhea) and help clinicians distinguish between the levels at which the drug remains tolerable and those that maximize therapeutic benefit
Significant changes suggest degradation has occurred
A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented
Xi J, Sun Y, Zhang M, Fa Z, Wan Y, Min Z, et al
An unopened pen can be stored at room temperature below 86 degrees Fahrenheit for up to 21 days
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