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It was longer lasting, so it only needed to be injected once a week, and clinical studies showed significant weight loss as a side effect
Oxcarbazepine, a derivative of carbamazepine that has better safety and tolerability, has also been reported to be effective in improving pain associated with DPN [69,70]
For now, patients and practitioners must navigate a landscape of uncertainty, weighing potential benefits against unproven risks and legal ambiguities
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
In the late 2000s, still haunted by the fallout from drugs like rosiglitazone (brand name Avandia), linked to increased heart attack risk, the FDA laid down a blunt new rule: every new diabetes drug must prove it wont harm the heart before it ever sees pharmacy shelves
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