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10 g of prebiotic fiber (the amount in 4 tsp of Flatter Me Fiber) was clinically shown to increase GLP-1 when taken with a meal compared to a placebo taken with the same meal in a randomized controlled trial

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This includes monitoring blood sugar, adjusting doses, and addressing any side effects

Neither peptide has been studied in combination in formal clinical trials, so this stack falls into the territory of informed experimentation based on how each compound works independently

In line with MHRA advice, metformin should generally be continued while B12 deficiency is investigated and treated, given its important role in diabetes management