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Enrolled patients had a baseline or recent liver biopsy showing clinically significant MASLD (metabolic dysfunction-associated steatotic liver disease), defined as MASH with fibrosis stage 2 or 3 and a non-alcoholic fatty liver disease (NAFLD) Activity Score (NAS) 4 with a score of 1 or more in steatosis, lobular inflammation, and hepatocyte ballooning
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This helps optimize absorption and avoids over-saturation Switch Nostrils : Use the other nostril for the next dose
Compounding a medication means a pharmacy custom-makes a replica of the medication, and this can happen for a number of clinical reasons or during a drug shortage
While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
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