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Nat Nanotechnol 2(9):577583

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We have shown that liraglutide administration increases NE levels in plasma and cecal contents

With over 138 million people in the US affected by obesity and increasing demand for effective treatments, the market is witnessing unprecedented expansion

Therefore, we found that the enhanced insulinotropic effect of exendin-phe1 in vitro is recapitulated in a mouse model of T2D, suggesting that GLP-1R trafficking plays a role in determining the responses to therapeutic GLP-1R agonists in vivo