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Glutathione is synthesized in the body from the amino acids L-cysteine, L-glutamic acid, and glycine

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Moreover, kynurenine directly inhibits T cell proliferation and induces the differentiation of nave T cells into Tregs, further suppressing the immune response ( IDO1 and kynurenine also promote the expansion of MDSCs, a population of immune cells that suppresses both innate and adaptive immune responses ( Figure 1A )