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doi:10.1111/dom.13962 17
It doesnt feel like a medical detail so much as a Tuesday routine, and for a second you wonder if it even counts
Interestingly, GI adverse events and GLP-1 RA discontinuations were more common in participants not treated with metformin, which may represent increased susceptibility of this group to gut-related adverse events, resulting in intolerance to metformin previously as well as to GLP-1 RAs in the trials
At the same time, IGFBP-3, the binding protein of IGF-1, can regulate the IGF-1 activity in tissues to some extent, and the molar ratio of IGF-1/IGF-BP-3 can unveil the number of IGF-1 with biological activity [30, 31, 32]
But that doesn't mean the story ends here
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