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In addition, a proportion of weight loss often comes from lean mass, with implications for metabolic health, strength, and long-term function
Medications make more sense for people with significant weight to lose for health reasons, those with type 2 diabetes or prediabetes where GLP-1 receptor agonists address both conditions simultaneously, individuals who have tried lifestyle changes and supplements without adequate results, and anyone whose healthcare provider recommends pharmaceutical intervention based on risk assessment
In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)
Sundberg CW, Fitts RH
2024:S1051-2276(24)0006000068 [pii]
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