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The topological properties of the drug-disease network were analyzed using Cytoscape software, as demonstrated in Figure 5D

Pharmacologically, cagrilintide is a dual amylin and calcitonin receptor agonist (DACRA) meaning it activates two related receptor systems at once

The peptide's upregulation of VEGFR2 at both mRNA and protein levels sensitizes healing tissues to angiogenic signals while its activation of the Src-Caveolin-1-eNOS pathway generates nitric oxide essential for vascular development and tissue perfusion

Peptides are usually discussed as an add-on, not the foundation