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Multiple clinical trials have established dosing ranges and administration protocols that optimize metabolic benefits while maintaining excellent safety profiles

The activation of VIP receptors stimulates the adenylyl cyclase to generate cytosolic cAMP that activate the cystic fibrosis transmembrane conductance regulator (CFTR), resulting in secretion of Cl into the lumen

References in this document to the NHS and NHS services include local authority public health services, but references to NHS bodies do not include local authorities

Minimizing side effects Most DSIP side effects result from excessive dosing