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Peer review Peer review information Nature Medicine thanks Jrn Schattenberg and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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End-of-week fatigue means easy wins

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Methodology of Drug Testing The methodology of drug testing involves several steps from sample collection to result interpretation: Sample Collection: Ensuring that the sample is collected in a way that minimizes the possibility of tampering is crucial

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Typical Escalation Schedule : Days 130: 3 mg daily (start dose) Days 3160: Escalate to 7 mg daily , if tolerated Day 61 onward: Possible increase to 14 mg daily , based on clinical response A missed dose should not be doubled

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doi: 10.3109/17453679809117617 187 BartokBFiresteinGS

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