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Around age 45, our glutathione levels start slipping

It also causes widespread oxidative damage to neuronal macromolecules, significantly contributing to the characteristic selective striatal neuronal loss in HD

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DeFronzo, R

In addition to GSH effects with T cells, a decrease in GSH plays similar roles in MS as it does in AD and PD, namely, to mark an increase in oxidative stress and inflammation in the respective disease ( Overall, a decrease in GSH is seen across AD, PD, and MS