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& Zwozdziak, B
The first converts homocysteine to methionine, which supports DNA synthesis and red cell production
There may be direct pharmacological effects through central GLP-1 pathways, as well as indirect consequences of the medication's intended actions and associated side effects
There's not enough to go around, the path forward is super unclear
Weight Loss Outcomes After Switching Trial data supports a higher average weight loss ceiling on tirzepatide: 20.9% at 72 weeks on 15mg (SURMOUNT-1) versus 14.9% at 68 weeks on 2.4mg semaglutide (STEP 1)
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