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Evidence from type 1 diabetes also points to an increase in GSH utilization, which in itself was associated with poorer glucose control.The perfect storm of obesity, oxidative stress, inflammation, adipocyte dysfunction, and the related metabolic abnormalities may also be linked by glutathione depletion
This drives increased appetite and slowed metabolism, making sustained weight loss difficult through diet alone
Evidence remains limited and more robust studies are required
One way to find a clinical trial is through clinicaltrials.gov
It is known that hypertension itself increases risk of OH [13], so it is likely the complex interaction between baseline risk of OH in well-controlled hypertensive patients and antihypertensive drug effects complicates the true picture
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