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Apoptosis, the most common form of PCD, is particularly significant, as granulosa cells apoptosis deprives oocytes of the hormones and survival factors essential for their meiotic and developmental competence, which increases the susceptibility of oocytes to apoptotic factors, ultimately impairing ovarian reserve function

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taken on an empty stomach or 30 minutes before meals to maximize contact with gastric and intestinal mucosa Duration 8 to 12 weeks per cycle, or longer under physician supervision for chronic GI conditions

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