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In signal detection, subgroup analyses, stratified analyses, and sensitivity analyses, the signals of product issues, injury, poisoning and procedural complications, social circumstances, and consistent with indications, which might cause by the product issues, inappropriate medication, disease progression, ineffective treatment, or other factors, were excluded
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In migraine prophylaxis, preclinical models suggest that topiramate dampens cortical spreading depression, attenuates trigeminovascular calcitonin-gene-related-peptide release, and down-regulates central nociceptive transmitter traffic-mechanisms distinct from its antiepileptic activity but still rooted in excitatory-inhibitory balance
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