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6 : 112 De Simone C, Catania S, Trinchieri V, Tzantzoglou S, Calvani M, Bagiella E
Although direct neo-N-terminal fragments of caspase-1 were not enriched in the TMT-TAILS dataset, potentially due to labeling inefficiencies, we observed significant depletion of peptides spanning the X(PC) cleavage site in the active protease-treated samples, providing strong evidence of on-target cleavage (Extended Data Fig
When glutathione levels decrease, for example, due to stress or nutritional deficiencies, the risk of catching a cold, getting infections, feeling constantly fatigued, or experiencing sleep disturbances significantly increases
This phenomenon is referred to as the oxidative burst or respiratory burst
These pathways not only preserve proteome integrity but also offer powerful therapeutic opportunities, as demonstrated by the emergence of proteasome inhibitors, autophagy modulators, and molecular chaperone-targeting agents in clinical medicine (Tables 1 and 2)
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