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Abstract Cancer remains one of the principal causes of death worldwide, with conventional treatments like chemotherapy and radiotherapy often exhibiting high toxicity, resistance, and relapse rates

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This article primarily outlines 11 methylation biomarkers ( ADHFE1, BMP3, CDX2, CYP24A1, DKK3, NSD2, SDC2, SEPT9, SFRP1, VIM ) that can be used for early screening of CRC

In fact, around 90% of drugs that show promise in preclinical testing ultimately fail in human trials

the gel capsule may be formed from hydroxypropyl methylcellulose (HPMC) or hypromellose