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Science 388 , eadk3487 (2025)
When the integrity of the BBB is breached, infiltrating blood components and immune cells activate perivascular glia, igniting an inflammatory cascade that accelerates neuronal damage
To overcome drug resistance and enhance its cytotoxicity, two derivatives of DOX were synthesized incorporating a sulfonamide moiety: 4-mononitrobenzenesulfonyl DOX (MNS-DOX) and 2,4-dinitrobenzenesulfonyl DOX (DNS-DOX) 94
-L- (PLC) -, -
PubMed Glyceryl ascorbate derivatives (2GA16) demonstrated dose-dependent suppression of interleukin-33 expression and increased expression of filaggrin and involucrin in keratinocytes
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