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and Europe Patent Number EP2818181, 2019
Translating laboratory-discovered resistance-reversal strategies into clinical practice faces multiple barriers, including biological complexity, economic constraints, data integration challenges, ethical concerns, and unequal access to advanced diagnostics and personalized therapies
Typically, treatment begins with a lower dosage and is scaled up as individuals acclimate to the side effects
Dasatinib has shown antifibrotic effects in keloid fibroblasts and xenotransplant keloid tissue in mice through the selective clearance of senescent cells and modulation of SASP, implying that dasatinib can be possibly used for senolytic treatment of keloids 15
GLP-1 receptor agonists may counteract this mechanism in multiple ways
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