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This is especially crucial with GLP-1s for weight loss due to the potential for reduced thirst and the need for adequate hydration to support fibers action and overall gut health while on GLP-1
Its biosynthesis is a two-step enzymatic cascade, including first a specific -ligation of glutamate and cysteine by -glutamate-cysteine ligase (GCL) and then the formation of peptide bond between this dipeptide and glycine by glutathione synthetase (GS)

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GLP-1 agonists were originally designed to treat Type 2 diabetes