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enm-2024-2164-Supplemental-Fig-S2.pdf Supplemental Fig
use of gastric ultrasound to assess residual volume before surgery
Published animal-model work reported that AOD-9604 produced fat-loss endpoints in obese rodent models without elevating IGF-1, without inducing insulin resistance, and without the cell-proliferation signaling normally associated with the full hGH receptor
These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46
Pregnancy or breastfeeding, since it is unclear if these drugs are safe for those groups
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