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Farxiga CKD Dosing : Standard dose: 10mg once daily Used when eGFR 25-75 mL/min/1.73m Continue even as eGFR declines to 25 mL/min/1.73m Monitor for volume depletion Jardiance CKD Dosing : Standard dose: 10mg once daily Used when eGFR 20 mL/min/1.73m May continue until dialysis initiation Regular kidney function monitoring is essential Both medications slow kidney function decline and may be continued longer than traditional diabetes medications as CKD progresses
Eating more fibre, lean protein, healthy fats, and water-rich fruits and vegetables can also increase GLP-1 levels naturally, supporting weight loss
It has been hypothesised that chemical stress, as represented by ROS, during strenuous exercise increases the permeability of muscle cells by peroxidation of the cell membranes 17,18 , thereby promoting leakage of the intracellular enzymes 19
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Compounded semaglutide and tirzepatide are available from compounding pharmacies at significantly lower cost, often $200-$400 per month
