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However, acetaminophen overdose is the leading cause for calls to Poison Control Centers (over 100,000/year)
Overall, the results of CVOTs published so far seems to suggest that the gap between the cardiorenal benefits of SGLT-2 and GLP-1RA is narrowing
Two patients of mine who took extended-release stimulants while on a GLP-1 agonist may have also seen increased development of tolerance to the stimulant effect
Weight loss also tends to follow a dose-response pattern, meaning higher doses generally produce greater average reductions in body fat
Weight loss generally begins within the first month but follows a gradual trajectory, with continued loss typically occurring for 9-12 months before plateauing
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