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Nitric oxide appears to influence Akt signaling though a cGMP/PI3K-dependent pathway [26], which is the primary pathway for up-regulating translation initiation and protein synthesis in skeletal muscle

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37 More research is needed, but three small studies of a multidisciplinary approach that includes physical, occupational, and cognitive behavior therapy have shown reduced anxiety, depression, catastrophizing, and kinesiophobia (fear of pain due to movement), with improved physical function and self-efficacy in treated patients