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Elimination: 17.4 hours Thomson/Micromedex

Los efectos adversos graves son poco frecuentes cuando la terapia es administrada adecuadamente por profesionales capacitados

This is not specific to B12 but reflects the sensitivity of the gastrointestinal tract in these conditions

pylori (the bacteria that may lead to ulcers), bloating, reflux, and upset stomach

Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation