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Lower TIMP-2 has been reported in other psychiatric disorders, including MDD (63), and schizophrenia (64)
Several models of inflammation are used to better understand these effects including viral RNA, systemic infection, non-infective systemic inflammation, inflammatory mediators, and cytokines, but the most widely accepted model is lipopolysaccharide (LPS) challenge
Despite its promising projections, the study has several limitations
Vagus nerve branches (right and left) were cautiously isolated along the oesophagus using a binocular loupe and sectioned in vagotomised mice or left integral in sham-operated ones
This dual mechanism is why clinical trials consistently show tirzepatide producing greater weight loss than semaglutide alone
