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Injections win for consistent dosing and trial-backed schedules
We employed an integrated cross-species framework that combined longitudinal preclinical studies in an established mouse model of TB meningitis utilizing clinical endpoints [mortality, neurological deficits, dynamic contrast-enhanced magnetic resonance imaging (MRI)] with parallel mechanistic studies in a newly developed 3D immune-vascularized human brain organoid model of TB meningitis and peripheral blood mononuclear cells (PBMCs) from patients with TB meningitis
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Additionally, as patents expire, a robust pipeline of generics and biosimilar versions of peptides will demand cost-effective manufacturing solutions (green chemistry, continuous processes) and global technology dissemination
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