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ShHTLs of the different clades showed distinct responses to SL, including natural SLs: strigol, 5-deoxystrigol (5DS), 4-deoxyorobanchol and sorgolactone, and a racemic mixture of the synthetic SL analog GR24 ( rac -GR24) or KAR in cross-species complementation assays, in which Arabidopsis kai2-2 and htl-3 mutants were transformed with ShHTLs genes: ShHTL1 is not responsive to KAR or SL
rare risks include pancreatic or thyroid issues
For persistent nausea that significantly impacts quality of life, antiemetic medications may be considered
Across studies, definitions of pregnancy-related endpoints, treatment duration, discontinuation structure, washout timing, concomitant metformin use, and post-treatment conception attempts vary substantially
A summary of clinically-significant GLP-1RAs described in this text and their clinical uses are listed in Table 1
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