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Its molecular target is nicotinamide N-methyltransferase (NNMT), a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, consuming SAM and releasing S-adenosylhomocysteine
Hence, supplementation of fish feed with microalgal extracts could act both to supply calcium chelators to reduce the fish allergenicity and decrease the need for fish meal as a supply of polyunsaturated fatty acids (PUFA), thus increasing the economic and environmental sustainability of aquaculture
Glucuronidation of SN-38, the active metabolite of irinotecan, by human hepatic microsomes
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