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In addition, lysine demethylase 4C (KDM4C) can also increase the expression of SSP genes by directly demethylating the promoter of SSP genes or ATF4, a transcriptional substrate of NRF2 (Denicola et al., 2015
Fitzpatrick, Denise Whitlock, and Shanae Wakefield
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The letter, posted online by Moderna, argued that the study did not include an adequate and well-controlled comparator reflecting the best-available standard of care, although neither federal regulations nor FDA guidance specifically require such a comparator
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