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Four of the included studies used the same dose for all patients while two studies utilized different doses for study patients
Each receptor system has its own adaptation timeline, its own threshold for side effects, and its own contribution to the overall metabolic response
For example, in the SUSTAIN 5 clinical trial, patients with HbA1c levels of 8.0% or lower had their basal insulin doses reduced by 20% when starting semaglutide therapy to minimize the risk of low blood sugar
The gradual dose escalation schedule is specifically designed to minimise these effects
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