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Our related article on GLP-1 Signaling, the Microbiome, and Hormones explains why GLP-1 biology is part of a larger metabolic network rather than a stand-alone weight-loss switch

2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances (Sekine et al., 2001)

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The minimum practical amount is 1mL, and 2mL is better