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Most side effect discomfort improves substantially by day 10 to 14 with dietary adjustments and hydration, so the first week is rarely representative of your long-term tolerability
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Over a multi-week protocol, this systematic underdosing compounds, potentially invalidating research outcomes
Weight loss in SUSTAIN-2 averaged 4.9 to 6.1 kg at 56 weeks on the combination vs 1.9 kg with metformin plus sitagliptin
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