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the leading candidate described in the literature is beta-3 adrenergic signaling in adipose tissue, which raises intracellular cyclic AMP, activates hormone-sensitive lipase and initiates triglyceride hydrolysis
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PMC Roles of nicotinamide N-methyltransferase in obesity and type 2 diabetes
It is also a highly effective option for patients who cannot tolerate the gastrointestinal side effects of gut-directed peptides
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