Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies
Overall, there is a strong association between common causes of ovarian reserve loss, such as aging, genetic variation, OS, radiation and chemotherapy, and ferroptosis, with disturbances in intracellular iron metabolism playing a central role in this process
Common side effects may include pain or redness at the injection site
Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
10.1016/j.tips.2022.04.003 37 ConfortiA.CarboneL.Di GirolamoR.IorioG