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Obesity-associated gut dysbiosis, characterized by homeostatic imbalance and barrier dysfunction, exacerbates muscle atrophy 11
GLP-1 drugs have garnered an increasing amount of media attention and some notable celebrity endorsements in the U.S., with much of the focus on their use for weight loss, though many of these drugs are also prescribed to treat diabetes or reduce risk of heart attack or stroke
However, in Harmony Outcomes, albiglutide reduced the risk of MACE by 22%, with 0.52% and 0.83 kg reductions in HbA1c and weight, respectively, compared with those in the placebo group [18]
But GLP-1 drugs are very expensive, especially in the United States
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