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CAPA must actually work (the #1 failure point) Minimum expectations: True root cause analysis (not symptoms) Documented effectiveness checks Trending across complaints, deviations, audits FDA red flags: CAPAs closed without proof of effectiveness Recurring issues ineffective CAPA If a problem repeats, FDA assumes your system is broken
These findings suggest attitudes towards injections are not consistent across the UK
Are these medications safe long term
This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures
Common observations include: Many patients report that friends or family begin noticing visible changes around this stage
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