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"The companies and the FDA, no one's identified an endgame with these drugs," Kessler says

Regarding safety in real-world practice, these large observational studies have not identified unexpected safety signals beyond those known from clinical trials

Effects of semaglutide on vessel morphology: Studies on the chicken chorioallantoic [PMID: 41125168] Laboratory literature summary: Effects of semaglutide on vessel morphology: Studies on the chicken chorioallantoic membrane