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Over the course of the three developmental ages, Escherichia coli lipopolysaccharides-induced nitrite levels in macrophages (increased nitric oxide synthase activity) ranged from 60 to 278 microM in the basal diet group, but they were significantly higher in all Spirulina dietary groups (0.5% group range = 198 to 457 microM

The central nervous system effects contribute primarily to nausea and reduced appetite, which are both therapeutic mechanisms and potential side effects depending on severity

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