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Reduced tetrahydrofolate may serve as an acceptor of one-carbon units via nitrogen-5 and nitrogen-10
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36,37 In addition, in diffuse large B-cell lymphoma (DLBCL) and colon cancer, silencing cNADK with shRNA impairs the pool of NADPH and suppresses cancer cell growth
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Compared with those in the WT group, the expression levels of these five genes were lower in the control group ( P = 0.1413, 0.0098, 0.0006, 0.0007, and 0.3512 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively), whereas the expression levels were significantly greater in the combination group than in the control group ( P = 0.0013, 0.0017, 0.0043, 0.0023, and 0.0016 for Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 , respectively) (Fig
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