364,365,366 Unlike other delivery carriers, INPs possess a stable and robust structure, a large specific surface area, and tunable surface properties, allowing precise control of the drug delivery process through surface functionalization and controlled release modifications
Ozempic is the injectable peptide GLP-1 medicine with the most FDA-approved uses in type 2 diabetes, with indications to improve blood sugar along with diet and exercise, to reduce the risk of major cardiovascular events (heart attack, stroke, or death) in adults who also have known heart disease, and to reduce the risk of worsening kidney disease, kidney failure (end-stage kidney disease), and death due to cardiovascular disease in adults who also have chronic kidney disease
Researchers never published the full results, although a short write-up in 2005 reported that the second trial found a positive effect but that it didnt reach statistical significance
Early trials suggest it may be effective not just on its own, but especially when combined with GLP-1 therapies, creating a powerful one-two punch against overeating and excess weight
Int J Mol Sci 2023