New GLP-1 drugs have emerged, including Eli Lillys tirzepatide (Mounjaro for diabetes, Zepbound for obesity), which activates both GLP-1 and GIP receptors and has produced even greater weight loss than semaglutide
Jung S et al
5 Even modest weight loss is clinically meaningful: reductions of 5% of baseline weight can improve blood pressure, glucose levels and cardiovascular risk
Their translational use is shaped by tissue penetration, lesion depth, light accessibility and the need for specialized activation devices, making them more suitable for superficial, endoscopically accessible or intraoperatively exposed lesions [73, 104]
That study reported changes in hormone-sensitive lipase activity, acetyl-CoA carboxylase activity, diacylglycerol release, adipocyte size, and body-weight gain in the specific models used