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Excessive activation could theoretically lower seizure thresholds, promote excitotoxicity, or disrupt the balance between excitatory and inhibitory neurotransmission

we observed a 11.7-fold change for venetoclax, a 18.4-fold change for AZD-5991, and an 5.5-fold change for ibrutinib

Due to the metabolic regulatory function of GLP-1RAs, they have also been considered for the treatment of other diseases such as obesity, liver disease and other metabolic dysfunction diseases (22)

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